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Recombinant Mouse THSD1/TMTSP Protein (His Tag)
Cat. No : CDRP-01146
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Target Information | |
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Target Name | THSD1/TMTSP |
Synonyms | Thrombospondin Type-1 Domain-Containing Protein 1; Transmembrane Molecule with Thrombospondin Module; THSD1; TMTSP |
UniProt ID | Q96PD4 |
Accession | NP_062522.1 |
Product Details | |
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Expression Host | HEK293 Cells |
Species | Mouse |
Tag | C-His |
Molar Mass | 45 kDa |
Sequence | Met 1-Val 423 |
Background |
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Thrombospondin type-1 domain-containing protein 1, also known as transmembrane molecule with thrombospondin module, THSD1 and TMTSP, is a single-pass type I membrane protein which contains one TSP type-1 domain. THSD1 is a multi-domain, multi-functional glycoprotein synthesized by many cells. Matricellular THSD1 modulates cell adhesion and proliferation. It is involved in angiogenesis, inflammation, wound healing and cancer. in vitro, nanomolar concentrations of Thrombospondin-1 are required to alter endothelial and vascular smooth muscle cell adhesion, proliferation, motility, and survival. As a major platelet protein, for a long time it was postulated to control hemostasis via platelet aggregate stabilization. THSD1 is a potent angiogenesis inhibitor, and down-regulation of THSD1 has been suggested to alter tumor growth by modulating angiogenesis in a variety of tumor types. |
Properties | |
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Purity | >95% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from sterile PBS, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.