Products
Online Inquiry
Recombinant Mouse Thrombomodulin Protein (His Tag)
Cat. No : CDRP-01143
size:
Target Information | |
---|---|
Target Name | Thrombomodulin |
Synonyms | Thrombomodulin; TM; Fetomodulin; CD141; BDCA-3; Thbd |
UniProt ID | Q96PD2 |
Accession | P15306 |
Product Details | |
---|---|
Expression Host | HEK293 Cells |
Species | Mouse |
Tag | C-His |
Molar Mass | 54.6 kDa |
Sequence | Ser 21-Leu 431 |
Background |
---|
Thrombomodulin is also known as CD141 antigen and blood dendritic cell antigen 3 (BDCA3), which is encoded by the THBD gene. The deduced amino acid sequence of mouse THBD predicts a signal peptide (aa 1 to 16) and a mature chain (aa 17 to 577) that consists of the following domains: C-type lectin, EGF-like, transmembrane and cytoplasmic. Mouse THBD is corresponding to the extracellular portion of the type I membrane protein. Predominantly synthesized by vascular endothelial cells, THBD inhibits coagulation and fibrinolysis. It functions as a cell surface receptor and an essential cofactor for active thrombin, which in turn activates protein C and thrombinactivatable fibrinolysis inhibitor (TAFI), also known as carboxypeptidase B2 (CPB2). In addition, THBD gene polymorphisims are associated with human disease and THBD plays a role in thrombosis, stroke, arteriosclerosis, and cancer. |
Properties | |
---|---|
Purity | >97% as determined by reducing SDS-PAGE. |
Formulation | Supplied as a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH8.0. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. |
Storage | Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles. |
! For research use only. Not intended for any clinical use.