Products
Online Inquiry
Recombinant Mouse SerpinE2/SERPINE2 Protein (His Tag)
Cat. No : CDRP-01124
size:
Target Information | |
---|---|
Target Name | SerpinE2/SERPINE2 |
Synonyms | Glia-derived Nexin; GDN; Peptidase inhibitor 7; PI-7; Protease nexin 1; PN-1; Protease nexin I; Serpin E2; SERPINE2; PI7; PN1 |
UniProt ID | Q8WZ75 |
Accession | Q07235 |
Product Details | |
---|---|
Expression Host | HEK293 Cells |
Species | Mouse |
Tag | C-His |
Molar Mass | 43.2 kDa |
Sequence | Ser 27-Ala 146 |
Background |
---|
Serpin E2 is a member of the Serpin superfamily of the serine protease inhibitors. Serpin E2 is apotent inhibitor of thrombin, plasmin and plasminogen activators. It is differentially expressed during neuronal differentiation and is able to transform humanembryonic kidney cells into neuronlikecells. Its over-expressionin mice leads to progressive neuronal and motor dysfunction in these animals. It is also over-expressedin the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples whereas it is weakly expressed in all normal pancreas and chronicpancreatitis tissue samples. It plays an important role in controlling male fertility because its knockout male mice show a marked impairment in fertility from theonset of sexual maturity and its abnormal expression is found in the semen of men with seminal dysfunction. |
Properties | |
---|---|
Purity | >97% as determined by reducing SDS-PAGE. |
Formulation | Supplied as a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH8.0. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. |
Storage | Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles. |
! For research use only. Not intended for any clinical use.