Recombinant Mouse Serpin F1/PEDF Protein (His Tag) (Active)
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Recombinant Mouse Serpin F1/PEDF Protein (His Tag) (Active)

Cat. No : CDRP-01114
size:
Target Information
Target Name Serpin F1/PEDF
Synonyms AI195227 Protein; Mouse; EPC-1 Protein; Mouse; Pedf Protein; Mouse; Pedfl Protein; Mouse; Sdf3 Protein; Mouse
UniProt ID Q8VC80
Accession NP_035470.3
Product Details
Expression Host HEK293 Cells
Species Mouse
Tag C-His
Molar Mass 45.8 kDa
Sequence Met 1-Ser 487
Application Functional ELISA
Background
Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein which has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. PEDF acts via multiple high affinity ligands and cell receptors. It has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. PEDF induces macrophages apoptosis and necrosis through the activation of peroxisome proliferator-activated receptor-gamma by which PEDF could modulate inflammatory reactions in septic shock. It balances angiogenesis in the eye and blocks tumor progression.
Properties
Purity >95% as determined by reducing SDS-PAGE.
Formulation Lyophilized from sterile PBS, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.