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Recombinant Mouse Serpin F1/PEDF Protein (His Tag) (Active)
Cat. No : CDRP-01114
size:
Target Information | |
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Target Name | Serpin F1/PEDF |
Synonyms | AI195227 Protein; Mouse; EPC-1 Protein; Mouse; Pedf Protein; Mouse; Pedfl Protein; Mouse; Sdf3 Protein; Mouse |
UniProt ID | Q8VC80 |
Accession | NP_035470.3 |
Product Details | |
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Expression Host | HEK293 Cells |
Species | Mouse |
Tag | C-His |
Molar Mass | 45.8 kDa |
Sequence | Met 1-Ser 487 |
Application | Functional ELISA |
Background |
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Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein which has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. PEDF acts via multiple high affinity ligands and cell receptors. It has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. PEDF induces macrophages apoptosis and necrosis through the activation of peroxisome proliferator-activated receptor-gamma by which PEDF could modulate inflammatory reactions in septic shock. It balances angiogenesis in the eye and blocks tumor progression. |
Properties | |
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Purity | >95% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from sterile PBS, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.