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Recombinant Mouse Semaphorin 4A/SEMA4A Protein (His Tag)
Cat. No : CDRP-01111
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Target Information | |
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Target Name | Semaphorin 4A/SEMA4A |
Synonyms | Semaphorin-4A; Semaphorin-B; Sema B; Sema4a; Semab; SemB |
UniProt ID | Q8SPW0 |
Accession | Q62178 |
Product Details | |
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Expression Host | HEK293 Cells |
Species | Mouse |
Tag | C-6His |
Molar Mass | 72.7 kDa |
Sequence | Asp 2-Ser 365 |
Background |
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Semaphorin-4A (SEMA4A) belongs to the semaphorin family which contains a Ig-like C2-type domain, a PSI domain and a Sema domain. SEMA4A is expressed from day 10 in the embryo, and low levels are found between days 10-12. SEMA4A is a cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. It plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. SEMA4A promotes phosphorylation of TIMD2, inhibits angiogenesis, and promotes axon growth cone collapse, Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. |
Properties | |
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Purity | >90% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from a 0.2 μm filtered solution of 20 mM PBS, 150 mM NaCl, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.