Recombinant Mouse REN1/Renin-1 Protein (His Tag)
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Recombinant Mouse REN1/Renin-1 Protein (His Tag)

Cat. No : CDRP-01101
size:
Target Information
Target Name REN1/Renin-1
Synonyms Renin-1; Angiotensinogenase; Kidney renin; Ren1; Ren; Ren-1; Angiotensin-forming enzyme; Ren-A; Ren1c; Ren1d; Rn-1; Rnr
UniProt ID Q8NHJ6
Accession P06281
Product Details
Expression Host HEK293 Cells
Species Mouse
Tag C-His
Molar Mass 43.5 kDa
Sequence Glu 22-Leu 401
Background
Mouse Renin, also known as Renin-1,is a member of the peptidase A1 amily. Renin is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. It cleaves angiotensinogen to generate angiotensin I, which can be further converted by angiotensin converting enzyme (ACE) to angiotensin II. Angiotensin II is the active molecule of the reninangiotensin system that acts by binding to angiotensin receptors type 1 and 2 (AT1 and AT2),and has direct pathophysiological effects on the heart and peripheral vasculature. After secretion, inactive prorenin can be proteolytically activated by trypsin, cathepsin B, or other proteinases.
Properties
Purity >90% as determined by reducing SDS-PAGE.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.