Recombinant Mouse RBP4 Protein (His Tag) (Active)
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Recombinant Mouse RBP4 Protein (His Tag) (Active)

Cat. No : CDRP-01100
size:
Target Information
Target Name RBP4
Synonyms RDCCAS; Retinol-Binding Protein 4; Plasma Retinol-Binding Protein; PRBP; RBP; RBP4
UniProt ID Q8NBP7
Accession NP_035385.1
Product Details
Expression Host HEK293 Cells
Species Mouse
Tag C-His
Molar Mass 22.8 kDa
Sequence Met 1-Ser 208
Application Functional ELISA
Background
Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A), and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily, RBP4 containing a β-barrel structure with a well-defined cavity is secreted from the liver, and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes, and its deficiency affects night vision largely. Recently, RBP4 as an adipokine, is found to be expressed in adipose tissue and correlated with obesity, insulin resistance (IR) and type 2 diabetes (T2DM).
Properties
Purity >95% as determined by reducing SDS-PAGE.
Formulation Lyophilized from sterile PBS, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.