Products
Online Inquiry
Recombinant Mouse Periostin/POSTN Protein (His Tag) (Active)
Cat. No : CDRP-01084
size:
Target Information | |
---|---|
Target Name | Periostin/POSTN |
Synonyms | A630052E07Rik; AI747096; OSF-2; Osf2; peri; PLF; PN |
UniProt ID | Q8BHC0 |
Accession | NP_056599.1 |
Product Details | |
---|---|
Expression Host | HEK293 Cells |
Species | Mouse |
Tag | C-His |
Molar Mass | 89 kDa |
Sequence | Met 1-Lys 282 |
Background |
---|
Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, as well as collagen fibrillogenesis. Postn is expressed in unique growth centers during embryonic development where it facilitates epithelial-mesenchymal transition (EMT) of select cell populations undergoing reorganization. In the adult, Postn expression is specifically induced in areas of tissue injury or areas with ongoing cellular re-organization. In the adult heart Postn is induced in the ventricles following myocardial infarction, pressure overload stimulation, or generalized cardiomyopathy. Although the detailed function of Postn is still unclear, Postn-integrin interaction is thought to be involved in tumor development. Postn is frequently overexpressed in various types of human cancers, stimulating metastatic growth by promoting cancer cell survival, invasion and angiogenesis, and can be a useful marker to predict the behavior of cancer. |
Properties | |
---|---|
Purity | >95% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from sterile PBS, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.