Products
Online Inquiry
Recombinant Mouse Motch A/NOTCH1 Protein (His Tag)
Cat. No : CDRP-01068
size:
Target Information | |
---|---|
Target Name | Motch A/NOTCH1 |
Synonyms | Neurogenic locus notch homolog protein 1; Notch 1; Motch A; Mt14; lin-12; Mis6; N1; Tan1 |
UniProt ID | Q6P6I8 |
Accession | Q01705 |
Product Details | |
---|---|
Expression Host | HEK293 Cells |
Species | Mouse |
Tag | C-His |
Molar Mass | 54.4 kDa |
Sequence | Glu 21-Arg 193 |
Background |
---|
Mouse Notch1 is a 300 kDa type I transmembrane glycoprotein and it functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Mouse Notch1 is synthesized as a 2531 amino acid (aa) precursor that contains an 18 aa signal sequence, a 1707 aa extracellular domain (ECD) with 36 EGFlike repeats and three Lin12/notch repeats, a 21 aa transmembrane segment and a 785 aa cytoplasmic domain that contains six ankyrin repeats, a glutamine-rich domain and a PEST sequence. Notch1 may play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation and may be involved in mesoderm development, somite formation and neurogenesis. |
Properties | |
---|---|
Purity | >90% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.