Recombinant Mouse Motch A/NOTCH1 Protein (His Tag)
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Recombinant Mouse Motch A/NOTCH1 Protein (His Tag)

Cat. No : CDRP-01068
size:
Target Information
Target Name Motch A/NOTCH1
Synonyms Neurogenic locus notch homolog protein 1; Notch 1; Motch A; Mt14; lin-12; Mis6; N1; Tan1
UniProt ID Q6P6I8
Accession Q01705
Product Details
Expression Host HEK293 Cells
Species Mouse
Tag C-His
Molar Mass 54.4 kDa
Sequence Glu 21-Arg 193
Background
Mouse Notch1 is a 300 kDa type I transmembrane glycoprotein and it functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Mouse Notch1 is synthesized as a 2531 amino acid (aa) precursor that contains an 18 aa signal sequence, a 1707 aa extracellular domain (ECD) with 36 EGFlike repeats and three Lin12/notch repeats, a 21 aa transmembrane segment and a 785 aa cytoplasmic domain that contains six ankyrin repeats, a glutamine-rich domain and a PEST sequence. Notch1 may play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation and may be involved in mesoderm development, somite formation and neurogenesis.
Properties
Purity >90% as determined by reducing SDS-PAGE.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.