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Recombinant Mouse Motch A/NOTCH1 Protein (His Tag) (Active)
Cat. No : CDRP-01069
size:
Target Information | |
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Target Name | Motch A/NOTCH1 |
Synonyms | Neurogenic locus notch homolog protein 1; Notch 1; Motch A; Mt14; lin-12; Mis6; N1; Tan1 |
UniProt ID | Q6P6I8 |
Accession | NP_032740.3 |
Product Details | |
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Expression Host | Baculovirus-Insect Cells |
Species | Mouse |
Tag | C-His |
Molar Mass | 55 kDa |
Sequence | Lys 22-Lys 89 |
Application | Functional ELISA |
Background |
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NOTCH1 is one of the four mammalian Notch receptors, which is involved in the Notch signaling pathway. Specifically, NOTCH1 promotes the proliferation of myogenic precursor cells, and the NICD domain of NOTCH1 can impair regeneration of skeletal muscles. NOTCH1 is a prevalent signaling pathway in T cell acute lymphoblastic leukemia (T-ALL). The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems. The proto-oncogene NOTCH1 is frequently mutated in around 1% of patients with chronic lymphocytic leukemia (CLL). NOTCH1 mutations in oral squamous cell carcinoma (OSCC) frequently occur near the ligand-binding region. These mutations change the domain structure of this protein and affect the ligand binding activity. When NOTCH1 is activated by ligand binding, NOTCH1 intracellular domain (NICD) is cleaved from the cell membrane. |
Properties | |
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Purity | >95% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.