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Recombinant Mouse Interleukin-13/IL-13 Protein (Active)
Cat. No : CDRP-01035
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| Target Information | |
|---|---|
| Target Name | Interleukin-13/IL-13 |
| Synonyms | ALRH; IL-13; P600; IL13 |
| UniProt ID | Q3SXB8 |
| Accession | P20109 |
| Product Details | |
|---|---|
| Expression Host | E.coli |
| Species | Mouse |
| Tag | None |
| Molar Mass | 12.2 kDa |
| Sequence | Ala 20-Pro 730 |
| Application | Cell Culture |
| Background |
|---|
| Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58% sequence identity with human protein and exhibits cross-species activity. IL13 signals via receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13Rα1 with low affinity and triggers association of IL4Rα, generating a high affinity heterodimeric receptor IL13R and eliciting downstream signals. IL13 also binds IL-13Rα2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease. |
| Properties | |
|---|---|
| Purity | >85% as determined by reducing SDS-PAGE. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20 mM PBS, 150 mM NaCl, pH7.2. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.