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Recombinant Mouse ANGPTL4 Protein (Fc Tag)
Cat. No : CDRP-00830
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Target Information | |
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Target Name | ANGPTL4 |
Synonyms | Angiopoietin-related protein 4; 425O18-1; Angiopoietin-like protein 4; Fasting-induced adipose factor; Hepatic fibrinogen/angiopoietin-related protein; HFARP; Secreted protein Bk89; Angptl4; Farp; Fiaf; Ng27 |
UniProt ID | P54619 |
Accession | Q9Z1P8 |
Product Details | |
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Expression Host | HEK293 Cells |
Species | Mouse |
Tag | C-Fc |
Molar Mass | 54.6 kDa |
Sequence | Trp 29-Phe 550 |
Background |
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Angiopoietin-related protein 4 (ANGPTL4) is a secreted protein and contains 1 fibrinogen C-terminal domain. The protein may act as a regulator of angiogenesis and modulate tumorigenesis. It inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 may exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation. |
Properties | |
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Purity | >98% as determined by reducing SDS-PAGE. |
Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. |
Storage | Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles. |
! For research use only. Not intended for any clinical use.