Recombinant Human VEGFR3/FLT4 Protein (Fc Tag) (Active)
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Recombinant Human VEGFR3/FLT4 Protein (Fc Tag) (Active)

Cat. No : CDRP-00796
size:
Target Information
Target Name VEGFR3/FLT4
Synonyms FLT-4; FLT-41; FLT41; LMPH1A; PCL; VEGF Receptor 3; VEGFR-3; VEGFR3
UniProt ID P49772
Accession NP_002011.2
Product Details
Expression Host HEK293 Cells
Species Human
Tag C-hFc
Molar Mass 111 kDa
Sequence Met 1-Lys 530
Application Functional ELISA
Background
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer (NSCLC), and so on.
Properties
Purity >95% as determined by reducing SDS-PAGE.
Formulation Lyophilized from sterile PBS, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.