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Recombinant Human VEGF-B/VEGFB Protein (Fc Tag)
Cat. No : CDRP-00783
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Target Information | |
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Target Name | VEGF-B/VEGFB |
Synonyms | Vascular endothelial growth factor B; VEGF-B; VEGF-related factor; VRF |
UniProt ID | P48357 |
Accession | P49765 |
Product Details | |
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Expression Host | HEK293 Cells |
Species | Human |
Tag | N-Fc |
Molar Mass | 45.7 kDa |
Sequence | Gly 24-Lys 238 |
Background |
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VEGFB, as known as VRF, is a member of the VEGF family of growth factors that share structural and functional similarity. By alternative splicing, two isoforms of mature VEGF-B containing 167 or 186 amino acid (aa) residues exist. VEGF-B is expressed in most tissues, especially in heart, skeletal muscle and pancreas. The two VEGF-B isoforms have identical amino-terminal cysteine-knot VEGF homology domains but the carboxyl end of VEGF-B167 differs from that of VEGF-B186 by the presence of a highly basic cysteine-rich heparin binding domain. VEGF-B167 and a proteolytically processed form of VEGF-B186 also bind neuropilin-1, a type I transmembrane receptor for semaphorins/collapsins, ligands involved in neuron guidance. |
Properties | |
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Purity | >94% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.