Recombinant Human VCAM1 Protein (His Tag)
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Recombinant Human VCAM1 Protein (His Tag)

Cat. No : CDRP-00770
size:
Target Information
Target Name VCAM1
Synonyms Vascular Cell Adhesion Protein 1; V-CAM 1; VCAM-1; INCAM-100; CD106; VCAM1; L1CAM
UniProt ID P43652
Accession NP_001069.1
Product Details
Expression Host Human Cells
Species Human
Tag C-6His
Molar Mass 75.3 kDa
Sequence Ala 11-Ser 154
Background
VCAM-1 is a single-pass type I membrane protein, contains 7 Ig-like C2-type domains. It is an endothelial ligand for very late antigen-4 (VLA-4) and α4?7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an 'endothelial cell gate' through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.
Properties
Purity >80% as determined by reducing SDS-PAGE.
Formulation Lyophilized from a 0.2 μm filtered solution of 20 mM PBS, 150 mM NaCl, 2 mM CaCl2, 2 mM MgCl2, 5% Threhalose, pH7.2.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.