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Recombinant Human Troponin C/TNNC1 Protein
Cat. No : CDRP-00752
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| Target Information | |
|---|---|
| Target Name | Troponin C/TNNC1 |
| Synonyms | CMD1Z; CMH13; TN-C; TNC; TNNC |
| UniProt ID | P42892 |
| Accession | NP_003271.1 |
| Product Details | |
|---|---|
| Expression Host | E.coli |
| Species | Human |
| Tag | None |
| Molar Mass | 18.4 kDa |
| Sequence | Leu 33-Phe 530 |
| Background |
|---|
| Troponin I, also known as TNNC1, is part of the troponin complex. This complex contains 3 subunits: troponin I (TnI), troponin T (TnT) and troponin C (TnC). Troponin I is the inhibitory subunit, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. |
| Properties | |
|---|---|
| Purity | >95% as determined by reducing SDS-PAGE. |
| Formulation | Lyophilized from sterile 150 mM NaCl, 10 mM Na2HPO4, pH7.5 |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.