Recombinant Human TRIB3/TRB3 Protein (GST Tag)
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Recombinant Human TRIB3/TRB3 Protein (GST Tag)

Cat. No : CDRP-00751
size:
Target Information
Target Name TRIB3/TRB3
Synonyms C20orf97; NIPK; SINK; SKIP3; TRB3
UniProt ID P42892
Accession NP_066981.2
Product Details
Expression Host Baculovirus-Insect Cells
Species Human
Tag N-GST
Molar Mass 65.8 kDa
Sequence Val 24-Pro 402
Background
Tribbles homolog 3, also known as Neuronal cell death-inducible putative kinase, p65-interacting inhibitor of NF-kappa-B, SINK and TRIB3, is a Nucleus protein which belongs to theprotein kinase superfamily and CAMK Ser/Thr protein kinase family and Tribbles subfamily. Highest expression Of TRIB3 is in liver, pancreas, peripheral blood leukocytes and bone marrow. It is also highly expressed in a number of primary lung, colon and breast tumors. TRIB3 is expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney. TRIB3 disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. TRIB3 may bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. It binds to ATF4 and inhibits its transcriptional activation activity. TRIB3 interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. It interacts with MAPK kinases and regulates activation of MAP kinases. It may play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. TRIB3 does not display kinase activity.
Properties
Purity >98% as determined by reducing SDS-PAGE.
Formulation Supplied as sterile solution of 50 mM Tris, 100 mM NaCl, pH8.0.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.
Storage Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles.

! For research use only. Not intended for any clinical use.