Recombinant Human TRIB2/TRB2 Protein (GST & His Tag)
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Recombinant Human TRIB2/TRB2 Protein (GST & His Tag)

Cat. No : CDRP-00750
size:
Target Information
Target Name TRIB2/TRB2
Synonyms C20orf97; NIPK; SINK; SKIP3; TRB3
UniProt ID P42830
Accession NP_067675.1
Product Details
Expression Host Baculovirus-Insect Cells
Species Human
Tag N-His & C-GST
Molar Mass 66 kDa
Sequence Val 22-Cys 167
Background
Tribbles homolog 2, also known as TRB-2, and Trib2, is a member of the protein kinase superfamily and Tribbles subfamily (Trib1, Trib2, Trib3). The identification of tribbles as regulators of signal processing systems and physiological processes, including development, together with their potential involvement in diabetes and cancer, has generated considerable interest in these proteins. Tribbles have been reported to regulate activation of a number of intracellular signalling pathways with roles extending from mitosis and cell activation to apoptosis and modulation of gene expression. Tribbles controls the timing of mitosis in the prospective mesoderm, allowing cell-shape changes to be completed. This mechanism for coordinating cell division and cell-shape changes may have helped Drosophila to evolve its mode of rapid early development. Trib2 was identified as a downregulated transcript in leukemic cells undergoing growth arrest. Trib2-transduced bone marrow cells exhibited a growth advantage and readily established factor-dependent cell lines. Trib2-reconstituted mice uniformly developed fatal transplantable acute myelogenous leukemia (AML).
Properties
Purity >98% as determined by reducing SDS-PAGE.
Formulation Supplied as sterile solution of 50 mM Tris, 100 mM NaCl, 0.5 mM PMSF, 0.5 mM GSH, pH8.0.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.
Storage Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles.

! For research use only. Not intended for any clinical use.