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Recombinant Human TREML1/TLT-1 Protein (Fc Tag)
Cat. No : CDRP-00748
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Target Information | |
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Target Name | TREML1/TLT-1 |
Synonyms | Trem-Like Transcript 1 Protein; TLT-1; Triggering Receptor Expressed on Myeloid Cells-Like Protein 1; TREML1; TLT1 |
UniProt ID | P42830 |
Accession | Q86YW5 |
Product Details | |
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Expression Host | HEK293 Cells |
Species | Human |
Tag | C-Fc |
Molar Mass | 42.9 kDa |
Sequence | Asp 25-Gln 267 |
Background |
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Triggering Receptor Expressed on Myeloid Cells-Like Protein 1 (TREML1) is a single-pass type I membrane protein. TREML1 precursor contains a 15 amino acid signal peptide; a 147 amino acid extracellular domain with an Ig-like V-type (immunoglobulin-like) domain; and 128 amino acid cytoplasmic domain. It can be expressed exclusively in platelets and megakaryocytes (MKs). It is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML1 Sequestered in cytoplasmic vesicles in resting platelets. TREML1 be transported to the cell surface after stimulation by thrombin. Soluble fragments can be released into the serum by proteolysis. The phosphorylated TREML1 can interact with PTPN6 and PTPN11. TREML1 may participate in maintaining vascular hemostasis and regulating coagulation and inflammation at sites of injury. |
Properties | |
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Purity | >90% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from a 0.2 μm filtered solution of 20 mM PBS, 150 mM NaCl, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.