Recombinant Human TRAILR1/TNFRSF10A Protein (Fc Tag) (Active)
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Recombinant Human TRAILR1/TNFRSF10A Protein (Fc Tag) (Active)

Cat. No : CDRP-00736
size:
Target Information
Target Name TRAILR1/TNFRSF10A
Synonyms APO2; CD261; DR4; MGC9365; TNFRSF10A; TRAILR-1; TRAILR1
UniProt ID P40763
Accession NP_003835.2
Product Details
Expression Host HEK293 Cells
Species Human
Tag C-hFc
Molar Mass 41.3 kDa
Sequence Met 1-Leu 158
Background
Tumor necrosis factor receptor superfamily, member 10a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF10A serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF10A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.
Properties
Purity >95% as determined by reducing SDS-PAGE.
Formulation Lyophilized from sterile PBS, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.