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Recombinant Human TRAIL Protein (Active)
Cat. No : CDRP-00731
size:
| Target Information | |
|---|---|
| Target Name | TRAIL |
| Synonyms | Tumor Necrosis Factor Ligand Superfamily Member 10; Apo-2 Ligand; Apo-2L; TNF-Related Apoptosis-Inducing Ligand; Protein TRAIL; CD253; TNFSF10; APO2L; TRAIL |
| UniProt ID | P37231 |
| Accession | P50591 |
| Product Details | |
|---|---|
| Expression Host | E.coli |
| Species | Human |
| Tag | None |
| Molar Mass | 19.5 kDa |
| Sequence | Ala 2201-Gly 2511 |
| Application | Cell Culture |
| Background |
|---|
| Human TNFSF10 is a type II transmembrane protein with an intracellular N-terminus and a ‘TNF homology domain’ (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct receptors. Two of these receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2/TRICK2), are plasma membrane proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells. |
| Properties | |
|---|---|
| Purity | >80% as determined by reducing SDS-PAGE. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 150 mM NaCl. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.