Recombinant Human TNFRSF1B/CD120b Protein (Fc Tag)

Cat. No : CDRP-00711

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Target Information
Target Name	TNFRSF1B/CD120b
Synonyms	CD120b; p75; p75TNFR; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80
UniProt ID	P35613-2
Accession	P20333

Product Details
Expression Host	HEK293 Cells
Species	Human
Tag	C-Fc
Molar Mass	51.9 kDa
Sequence	Ile 27-Ser 159

Background
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosis factor receptor superfamily. Human TNF RII contains four cysteinerich repeats in its ECD; which shares 58% and 56% amino acid sequence identity with the mouse and rat orthologs; respectively. TNF RII is expressed predominantly on cells of the hematopoietic lineage; such as T and natural killer cells; as well as on endothelial cells; microglia; astrocytes;neurons; oligodendrocytes; cardiac myocytes; thymocytes; and mesenchymal stem cells. TNF RII binds to the membranebound forms of TNFα and Lymphotoxinα/TNFβ soluble TNF is thought to signal predominately through TNF RI. Soluble TNF RII is believed to inhibit TNF biological activity by binding TNF thereby preventing it from activating membrane TNF receptors.

Background

Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosis factor receptor superfamily. Human TNF RII contains four cysteinerich repeats in its ECD; which shares 58% and 56% amino acid sequence identity with the mouse and rat orthologs; respectively. TNF RII is expressed predominantly on cells of the hematopoietic lineage; such as T and natural killer cells; as well as on endothelial cells; microglia; astrocytes;neurons; oligodendrocytes; cardiac myocytes; thymocytes; and mesenchymal stem cells. TNF RII binds to the membranebound forms of TNFα and Lymphotoxinα/TNFβ soluble TNF is thought to signal predominately through TNF RI. Soluble TNF RII is believed to inhibit TNF biological activity by binding TNF thereby preventing it from activating membrane TNF receptors.

Properties
Purity	>95% as determined by reducing SDS-PAGE.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution	Please refer to the printed manual for detailed information.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.