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Recombinant Human Tie2 Protein (His & Fc Tag) (Active)
Cat. No : CDRP-00668
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Target Information | |
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Target Name | Tie1 |
Synonyms | CD202B; TIE-2; TIE2; VMCM; VMCM1 |
UniProt ID | P29965 |
Accession | NP_000450.2 |
Product Details | |
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Expression Host | HEK293 Cells |
Species | Human |
Tag | C-His & Fc |
Molar Mass | 108.5 kDa |
Sequence | Leu 25-Glu 524 |
Application | Functional ELISA |
Background |
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TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature. |
Properties | |
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Purity | >95% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from sterile 100 mM Glycine, 10 mM NaCl, 50 mM Tris, pH7.5 |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.