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Recombinant Human Tie1 Protein (His Tag)
Cat. No : CDRP-00665
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| Target Information | |
|---|---|
| Target Name | Tie1 |
| Synonyms | Tyrosine-Protein Kinase Receptor Tie-1; TIE1; TIE |
| UniProt ID | P29622 |
| Accession | P35590 |
| Product Details | |
|---|---|
| Expression Host | HEK293 Cells |
| Species | Human |
| Tag | C-6His |
| Molar Mass | 81 kDa |
| Sequence | Ala 101-Leu 742 |
| Background |
|---|
| TIE-1 (Tyrosine Kinase with Ig and EGF Homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily. These receptors are expressed on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18aa signal peptide, a 727 aa extracellular domain and a 354 aa cytoplasmic domain. so far, two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)], but no ligand was found for TIE-1. |
| Properties | |
|---|---|
| Purity | >80% as determined by reducing SDS-PAGE. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20 mM MES, 150 mM NaCl, pH5.5. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.