Products
Online Inquiry
Recombinant Human Thrombomodulin Protein (His Tag)
Cat. No : CDRP-00661
size:
Target Information | |
---|---|
Target Name | Thrombomodulin |
Synonyms | Thrombomodulin; THBD; TM; Fetomodulin; CD141; THRM |
UniProt ID | P29323-3 |
Accession | P07204 |
Product Details | |
---|---|
Expression Host | HEK293 Cells |
Species | Human |
Tag | C-His |
Molar Mass | 52.9 kDa |
Sequence | Ser 22Thr 356 |
Background |
---|
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Human Thrombomodulin/THBD predicts a signal peptide and a mature chain that consists of following domains: C-type lectin, EGF-like, transmembrane and cytoplasmic. Predominantly synthesized by vascular endothelial cells, THBD inhibits coagulation and fibrinolysis. THBD gene polymorphisims are associated with human disease and THBD plays a role in thrombosis, stroke, arteriosclerosis, and cancer. For example, increased serum levels of THBD, due to protease cleavage, have been associated with smoking, cardiac surgery, atherosclerosis, liver cirrhosis, diabetes mellitus, cerebral and myocardial infarction, and multiple sclerosis. |
Properties | |
---|---|
Purity | >97% as determined by reducing SDS-PAGE. |
Formulation | Supplied as a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH8.0. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. |
Storage | Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles. |
! For research use only. Not intended for any clinical use.