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Recombinant Human TGFB3 Protein (Active)
Cat. No : CDRP-00648
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Target Information | |
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Target Name | TGFB3 |
Synonyms | Transforming growth factor beta-3; TGFB3; TGF-beta-3; Latency-associated peptide; LAP |
UniProt ID | P28906 |
Accession | P10600 |
Product Details | |
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Expression Host | HEK293 Cells |
Species | Human |
Tag | None |
Molar Mass | 12.7 kDa |
Sequence | Gln 283-Arg 396 |
Background |
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Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3 becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development. It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3, mammals develop a deformity known as a cleft palate. |
Properties | |
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Purity | >90% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from a 0.2 μm filtered solution of 4 mM HCl. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.