Recombinant Human SPEG/APEG-1 Protein (His Tag)
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Recombinant Human SPEG/APEG-1 Protein (His Tag)

Cat. No : CDRP-00603
size:
Target Information
Target Name SPEG/APEG-1
Synonyms APEG-1; APEG1; BPEG; CNM5; SPEGalpha; SPEGbeta
UniProt ID P23141-3
Accession Q15772-4
Product Details
Expression Host E.coli
Species Human
Tag C-His
Molar Mass 14 kDa
Sequence Val 77-Leu 233
Background
Striated muscle preferentially expressed protein kinase, also known as aortic preferentially expressed protein 1, APEG-1, SPEG and KIAA1297, is a protein which belongs to theprotein kinase superfamily and CAMK Ser/Thr protein kinase family. SPEG/APEG-1 contains twofibronectin type-III domains, nine Ig-like (immunoglobulin-like) domains, two protein kinase domains. Isoform1of SPEG is preferentially expressed in striated muscle. Non-kinase form such as isoform3of SPEG is predominantly expressed in the aorta. Isoform3of SPEG appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC. Isoform3of SPEG may have a role in regulating the growth and differentiation of arterial smooth muscle cells. Isoform3of SPEG is quickly down-regulated in response to vascular injury, when ASMC cells change from a quiescent to a proliferative phenotype.
Properties
Purity >98% as determined by reducing SDS-PAGE.
Formulation Supplied as sterile solution of PBS, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.
Storage Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles.

! For research use only. Not intended for any clinical use.