Recombinant Human SOD2/Mn-SOD Protein (His Tag)

Cat. No : CDRP-00600

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Target Information
Target Name	SOD2/Mn-SOD
Synonyms	Superoxide Dismutase [Mn] Mitochondrial; SOD2
UniProt ID	P22894
Accession	P04179

Product Details
Expression Host	E.coli
Species	Human
Tag	N-6His
Molar Mass	23.7 kDa
Sequence	Ser 27-Ala 146

Background
Superoxide Dismutase (SOD2) is a number of the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. The SOD2 protein transforms toxic superoxide and a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. Genetic variation in SOD2 is associated with microvascular complications of diabetes type 6 (MVCD6); idiopathic cardiomyopathy (IDC); sporadic motor neuron disease; and cancer. SOD2 destroys superoxide anion radicals which are usually produced within the cells and which are toxic to biological systems.

Background

Superoxide Dismutase (SOD2) is a number of the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. The SOD2 protein transforms toxic superoxide and a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. Genetic variation in SOD2 is associated with microvascular complications of diabetes type 6 (MVCD6); idiopathic cardiomyopathy (IDC); sporadic motor neuron disease; and cancer. SOD2 destroys superoxide anion radicals which are usually produced within the cells and which are toxic to biological systems.

Properties
Purity	>97% as determined by reducing SDS-PAGE.
Formulation	Supplied as a 0.2 μm filtered solution of 20 mM Tris, 100 mM NaCl, 10% Glycerol, pH8.0.
Reconstitution	Please refer to the printed manual for detailed information.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.
Storage	Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles.

! For research use only. Not intended for any clinical use.