Recombinant Human SH2D1A/SAP Protein (His Tag) (Active)
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Recombinant Human SH2D1A/SAP Protein (His Tag) (Active)

Cat. No : CDRP-00584
size:
Target Information
Target Name SH2D1A/SAP
Synonyms SH2 Domain-Containing Protein 1A; Duncan Disease SH2-Protein; Signaling Lymphocytic Activation Molecule-Associated Protein; SLAM-Associated Protein; T-Cell Signal Transduction Molecule SAP; SH2D1A; DSHP; EBVS; IMD5; LYP; MTCP1; SAP/SH2D1A; XLP; XLPD; XLPD1
UniProt ID P21695
Accession NP_002342.1
Product Details
Expression Host E.coli
Species Human
Tag N-His
Molar Mass 15.6 kDa
Sequence Pro 143-Ser 288
Application Functional ELISA
Background
SH2 domain-containing protein 1A (SH2D1A/SAP) is a 128 amino acid protein, containing a single Src homology 2 (SH2) domain, flanked by 5 amino acids at the N-terminus and 25 amino acids at the C-terminus. The absence of a catalytic domain and the presence of an SH2 domain suggest that SH2D1A regulates one or more signal transduction pathways. SH2D1A interacts with signaling lymphocytic activation molecule (SLAM), which is a transmembrane protein expressed on the surface of activated T and B cells. SH2D1A (SAP) interacts via its SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of the cell-surface receptors, including CD150/SLAM, CD84, CD229/Ly-9, and CD244/2B4. SH2D1A was expressed in EBV-carrying, tumor phenotype representative (type I), but not in EBV-carrying lymphoblastoid cell line (LCL)-like (type III) or EBV-negative Burkitt lymphoma (BL) lines. It has been supposed to be related to the X-linked lymphoproliferative disease which is also known as Duncan's disease or Purtilo syndrome.
Properties
Purity >95% as determined by reducing SDS-PAGE.
Formulation Lyophilized from sterile PBS, pH7.5, 20% Glycerol
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.