Recombinant Human SerpinE2/SERPINE2 Protein (His Tag)
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Recombinant Human SerpinE2/SERPINE2 Protein (His Tag)

Cat. No : CDRP-00572
size:
Target Information
Target Name SerpinE2/SERPINE2
Synonyms Glia-derived Nexin; GDN; Peptidase inhibitor 7; PI-7; Protease nexin 1; PN-1; Protease nexin I; Serpin E2; SERPINE2; PI7; PN1
UniProt ID P20809
Accession P07093-2
Product Details
Expression Host HEK293 Cells
Species Human
Tag C-His
Molar Mass 42.7 kDa
Sequence Ser 22-Gly 353
Background
Serpin E2 is a secreted protein that belongs to the serpin family. Serpin E2 is a serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Serpin E2 expression is weak or absent in all normal pancreas and chronic pancreatitis tissue. In contrast, it was strongly over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples. Serpin E2 promotes neurite extension by inhibiting thrombin. It also can bind heparin. It has been shown that Serpin E2 is a novel target of ERK signaling involved in human colorectal tumorigenesis. It plays an important role in controlling male fertility because its knockout male mice show a marked impairment in fertility from the onset of sexual maturity and its abnormal expression is found in the semen of men with seminal dysfunction.
Properties
Purity >97% as determined by reducing SDS-PAGE.
Formulation Supplied as a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH8.0.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.
Storage Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles.

! For research use only. Not intended for any clinical use.