Recombinant Human SERPINB1/PI2 Protein (Human Cells, His Tag)
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Recombinant Human SERPINB1/PI2 Protein (Human Cells, His Tag)

Cat. No : CDRP-00563
size:
Target Information
Target Name SERPINB1/PI2
Synonyms Leukocyte elastase inhibitor; SERPINB1; Monocyte/neutrophil elastase inhibitor; M/NEI; Peptidase inhibitor 2; PI-2; PI2; EI; ELANH2; HEL-S-27; HEL57; LEI; MNEI
UniProt ID P20248
Accession P30740
Product Details
Expression Host HEK293 Cells
Species Human
Tag C-6His
Molar Mass 43.8 kDa
Sequence Cys 24-Asn 144
Background
SERPINB1 is a member of the serpin family and Ov-serpin subfamily. As protease inhibitors; serpins have an array of functions including regulating blood coagulation; fibrinolysis; the complement pathway; angiogenesis; inflammation; tumor suppression; extracellular matrix remodeling; and cell motility. SERPINB1 regulates the activity of the neutrophil proteases elastase; cathepsin G; proteinase-3; chymase; chymotrypsin; and kallikrein-3. Reactive bond 1 of SerpinB1 is specific for reaction with chymotrypsin-like protease such as cathepsin G; chymotrypsin or chymase. Reactive bond 2 of SerpinB1 is specific for reaction with elastase-like protease such as neutrophyl elastase; proteinase-3; pancreatic elastase or PSA. In addition; SERPINB1 also functions as a potent intracellular inhibitor of granzyme H.
Properties
Purity >90% as determined by reducing SDS-PAGE.
Formulation Lyophilized from a 0.2 μm filtered solution of 20 mM PBS, 150 mM NaCl, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.