Recombinant Human RELA/Transcription Factor p65/NFkB p65 Protein (aa 1-306, GST Tag)
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Recombinant Human RELA/Transcription Factor p65/NFkB p65 Protein (aa 1-306, GST Tag)

Cat. No : CDRP-00526
size:
Target Information
Target Name RELA/Transcription Factor p65/NFkB p65
Synonyms NFKB3; p65
UniProt ID P17213
Accession Q04206-1
Product Details
Expression Host E.coli
Species Human
Tag N-GST
Molar Mass 62 kDa
Sequence Leu 49-Ser 177
Background
RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a transcription factor expressed in growth plate chondrocytes where it facilitates chondrogenesis. The v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) gene encodes the major component of the NF-kB complex. NF-kappaB is a generic name for an evolutionarily conserved transcription-factor system that contributes to the mounting of an effective immune response but is also involved in the regulation of cell proliferation, development, and apoptosis. The implication of NF-kappaB in central biological processes and its extraordinary connectivity to other signaling pathways raise a need for highly controlled regulation of NF-kappaB activity at several levels. The mammalian Rel/NF-kappaB family of transcription factors, including RelA, c-Rel, RelB, NF-kappaB1 (p50 and its precursor p105), and NF-kappaB2 (p52 and its precursor p100), plays a central role in the immune system by regulating several processes ranging from the development and survival of lymphocytes and lymphoid organs to the control of immune responses and malignant transformation.
Properties
Purity >95% as determined by reducing SDS-PAGE.
Formulation Lyophilized from sterile 20 mM Tris, 0.15M NaCl, 20 mM GST, pH8.0.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.