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Recombinant Human RBP4 Protein (His Tag) (Active)
Cat. No : CDRP-00525
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Target Information | |
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Target Name | RBP4 |
Synonyms | RDCCAS; Retinol-Binding Protein 4; Plasma Retinol-Binding Protein; PRBP; RBP; RBP4 |
UniProt ID | P17047 |
Accession | NP_006735.2 |
Product Details | |
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Expression Host | HEK293 Cells |
Species | Human |
Tag | C-His |
Molar Mass | 23 kDa |
Sequence | Met 1-Arg 399 |
Application | Functional ELISA |
Background |
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Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A); and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily; RBP4 containing a β-barrel structure with a well-defined cavity is secreted from the liver; and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma; the RBP4-retinol complex interacts with transthyretin (TTR); and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes; and its deficiency affects night vision largely. Recently; RBP4 as an adipokine; is found to be expressed in adipose tissue and correlated with obesity; insulin resistance (IR) and type 2 diabetes (T2DM). |
Properties | |
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Purity | >95% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from sterile PBS, pH7.2 |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.