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Recombinant Human PTP1B/PTPN1 Protein (His Tag) (Active)
Cat. No : CDRP-00513
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Target Information | |
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Target Name | PTP1B/PTPN1 |
Synonyms | PTP1B; PTPN1 |
UniProt ID | P16406 |
Accession | NP_002818.1 |
Product Details | |
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Expression Host | E.coli |
Species | Human |
Tag | N-His |
Molar Mass | 38 kDa |
Sequence | Val 77-Leu 233 |
Background |
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PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein phosphatase domain and is expressed in many tissues. PTP1B is localized to the cytoplasmic face of the endoplasmic reticulum. PTP1B was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of PTP1B in cell growth control, and cell response to IFN stimulation. |
Properties | |
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Purity | >98% as determined by reducing SDS-PAGE. |
Formulation | Supplied as sterile solution of PBS, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. |
Storage | Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles. |
! For research use only. Not intended for any clinical use.