Recombinant Human PSGL-1/CD162 Protein (Fc Tag)
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Recombinant Human PSGL-1/CD162 Protein (Fc Tag)

Cat. No : CDRP-00510
size:
Target Information
Target Name PSGL-1/CD162
Synonyms P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162; SELPLG; CLA; PSGL1
UniProt ID P16284
Accession Q14242
Product Details
Expression Host HEK293 Cells
Species Human
Tag C-Fc
Molar Mass 52.7 kDa
Sequence Gln 16-Pro 162
Background
PSGL-1 (CD162), is a mucintype glycoprotein that plays a key role in leukocyte adhesion. Human PSGL-1 cDNA encodes 412 amino acids (aa). It expressed on neutrophils, monocytes and most lymphocytes. The mature PSGL-1 (aa 42-412) is expressed as a disulfide-linked homodimer that signals intracellularly and promotes integrin activation. PSGL-1 is found on virtually all leukocytes, dendritic cells, platelets, and some endothelial cells. It is primarily responsible for early events in extravasation, especially rolling adhesion of leukocytes to vascular endothelium. Through high affinity, This SLe(x)-type proteoglycanPGSL-1 calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation.
Properties
Purity >90% as determined by reducing SDS-PAGE.
Formulation Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH8.0.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.