Recombinant Human Plasma Kallikrein/KLKB1 Protein (His Tag)

Cat. No : CDRP-00481

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Target Information
Target Name	Plasma Kallikrein/KLKB1
Synonyms	Plasma kallikrein; Fletcher factor; Kininogenin; Plasma prekallikrein; KLKB1; KLK3
UniProt ID	P14921-5
Accession	P03952

Product Details
Expression Host	HEK293 Cells
Species	Human
Tag	C-6His
Molar Mass	70.2 kDa
Sequence	Ser 97-Pro 448

Background
KLKB1 is a 638 amino acids protein that belongs to the peptidase S1 family and plasma kallikrein subfamily. It contains a peptidase S1 domain and four apple domains. The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. It participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.

Background

KLKB1 is a 638 amino acids protein that belongs to the peptidase S1 family and plasma kallikrein subfamily. It contains a peptidase S1 domain and four apple domains. The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. It participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.

Properties
Purity	>97% as determined by reducing SDS-PAGE.
Formulation	Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl,150 mM NaCl,10% Glycerol, pH8.0.
Reconstitution	Please refer to the printed manual for detailed information.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.
Storage	Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles.

! For research use only. Not intended for any clinical use.