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Recombinant Human PFKFB3 Protein (N-6His)
Cat. No : CDRP-00465
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Target Information | |
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Target Name | PFKFB3 |
Synonyms | IPFK2; PFK2; iPFK-2; PFK/FBPase 3 |
UniProt ID | P13987 |
Accession | Q16875 |
Product Details | |
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Expression Host | E.coli |
Species | Human |
Tag | N-6His |
Molar Mass | 61.8 kDa |
Sequence | Thr 25-Pro 242 |
Background |
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Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis. Highly phosphorylated PFKFB3 protein was found in human tumor cells, vascular endothelial cells, and smooth muscle cells. Because of its proto-oncogenic character, the PFK-2/FBPase-2 of the PFKFB3 gene is assumed to play a critical role in tumorigenesis. PFKFB3 also plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways even under severe hypoxic conditions, which makes it a potential target for cancer therapy. |
Properties | |
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Purity | >97% as determined by reducing SDS-PAGE. |
Formulation | Supplied as a 0.2 μm filtered solution of 50 mM Tris-HCl, 50 mM KCl, 1 mM DTT, 0.1 mM EDTA, 20% Glycerol, pH8.0. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. |
Storage | Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles. |
! For research use only. Not intended for any clinical use.