Recombinant Human Peroxiredoxin 1/PRDX1 Protein (His Tag)
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Recombinant Human Peroxiredoxin 1/PRDX1 Protein (His Tag)

Cat. No : CDRP-00455
size:
Target Information
Target Name Peroxiredoxin 1/PRDX1
Synonyms Peroxiredoxin-1; Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2; PAGA; PAGB; TDPX2; MSP23; NKEF-A; NKEFA; PAG; PRX1; PRXI; TDPX2
UniProt ID P13726
Accession Q06830
Product Details
Expression Host E.coli
Species Human
Tag N-His & C-His
Molar Mass 25.3 kDa
Sequence Thr 32-His 266
Background
Peroxiredoxin-1(PRDX1) contains 1 thioredoxin domain and belongs to the AhpC/TSA family. PRDX1 constitutively expressed in most human cells and it is induced to higher levels upon serum stimulation in untransformed and transformed cells. PRDX1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and play an important role in eliminating peroxides generated during metabolism. PRDX1 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. It reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. It may contribute to the antiviral activity of CD8(+) T-cells and have a proliferative effect in cancer development or progression.
Properties
Purity >97% as determined by reducing SDS-PAGE.
Formulation Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, 0.1 mM DTT, pH6.0.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.
Storage Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles.

! For research use only. Not intended for any clinical use.