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Recombinant Human PCSK9 Protein (AVI Tag) (Active)
Cat. No : CDRP-00432
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| Target Information | |
|---|---|
| Target Name | PCSK9 |
| Synonyms | Proprotein Convertase Subtilisin/Kexin Type 9; Neural Apoptosis-Regulated Convertase 1; NARC-1; Proprotein Convertase 9; PC9; Subtilisin/Kexin-Like Protease PC9; PCSK9; NARC1 |
| UniProt ID | P12643 |
| Accession | Q8NBP7 |
| Product Details | |
|---|---|
| Expression Host | HEK293 Cells |
| Species | Human |
| Tag | C-AVI |
| Molar Mass | 14 & 59 kDa |
| Sequence | Thr 52-Asn 151 |
| Application | Functional ELISA |
| Background |
|---|
| Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER ; the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2); and play a role in the neural development. |
| Properties | |
|---|---|
| Purity | >97% as determined by reducing SDS-PAGE. |
| Formulation | Supplied as a 0.2 μm filtered solution of 50 mM HEPES,150 mM NaCl,20% Glycerol, pH7.4. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. |
| Storage | Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles. |
! For research use only. Not intended for any clinical use.