Recombinant Human P-selectin/CD62P Protein (C-Fc)
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Recombinant Human P-selectin/CD62P Protein (C-Fc)

Cat. No : CDRP-00509
size:
Target Information
Target Name P-selectin/CD62P
Synonyms P-selectin; CD62 antigen-like family member P; Granule membrane protein 140;   GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; PADGEM
UniProt ID P16284
Accession P16109
Product Details
Expression Host HEK293 Cells
Species Human
Tag C-Fc
Molar Mass 106.9 kDa
Sequence Glu 19-Glu 144
Background
P-selectin/CD62P is a single-pass type I membrane protein which is a member of the Selectin family. It consists 768 amino acid (aa). P-selectin is a cell surface glycoprotein expressed by activated platelets and endothelial cells. It induced expression in lung, liver, kidney and heart after endotoxin treatment. Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. It mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. it also mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. P-selectin interacts with SNX17, PSGL1/SEPL, PODXL2, mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1.
Properties
Purity >90% as determined by reducing SDS-PAGE.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.