Products
Online Inquiry
Recombinant Human NGAL/Lipocalin-2 Protein (His Tag, E.coli)
Cat. No : CDRP-00392
size:
Target Information | |
---|---|
Target Name | NGAL/Lipocalin-2 |
Synonyms | Neutrophil gelatinase-associated lipocalin; NGAL; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25; HNL; NGAL |
UniProt ID | P10092 |
Accession | P80188 |
Product Details | |
---|---|
Expression Host | E.coli |
Species | Human |
Tag | C-6His |
Molar Mass | 21.8 kDa |
Sequence | Trp 39-Asn 332 |
Background |
---|
Neutrophil gelatinase-associated lipocalin(LCN2) is a secreted protein and belongs to the calycin superfamily. This protein is released from injured tubular cells after various damaging stimuli; is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover; recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores; which are high-affinity iron chelators. NGAL; first known as an antibacterial factor of natural immunity; and an acute phase protein; is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation; NGAL has a clear pro-tumoral effect; as has already been observed in different tumors (e. g. breast; stomach; oesophagus; brain) in humans. In thyroid carcinomas; NGAL is strongly induced by NF-kB; an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus; Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation; proliferation; survival and morphogenesis. |
Properties | |
---|---|
Purity | >98% as determined by reducing SDS-PAGE. |
Formulation | Supplied as a 0.2 μm filtered solution of PBS,50% Glycerol, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. |
Storage | Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles. |
! For research use only. Not intended for any clinical use.