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Recombinant Human NGAL/Lipocalin-2 Protein (His Tag, Human Cells)
Cat. No : CDRP-00399
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Target Information | |
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Target Name | NGAL/Lipocalin-2 |
Synonyms | Neutrophil gelatinase-associated lipocalin; NGAL; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25; HNL; NGAL |
UniProt ID | P10148 |
Accession | P80188 |
Product Details | |
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Expression Host | HEK293 Cells |
Species | Human |
Tag | C-6His |
Molar Mass | 21.6 kDa |
Sequence | Thr 34-Leu 328 |
Background |
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LCN2 is iron-trafficking protein involved in multiple processes such as apoptosis; innate immunity and renal development. LCN2 binds iron through association with 2;5-dihydroxybenzoic acid (2;5-DHBA); a siderophore that shares structural similarities with bacterial enterobactin; and delivers or removes iron from the cell; depending on the context. LCN2 is involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis; while iron-free form decreases intracellular iron levels; inducing expression of the proapoptotic protein BCL2L11/BIM; resulting in apoptosis. LCN2 is involved in innate immunity; possibly by sequestrating iron; leading to limit bacterial growth. |
Properties | |
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Purity | >98% as determined by reducing SDS-PAGE. |
Formulation | Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. |
Storage | Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles. |
! For research use only. Not intended for any clinical use.