Recombinant Human NGAL/Lipocalin-2 Protein (His Tag, Human Cells)
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Recombinant Human NGAL/Lipocalin-2 Protein (His Tag, Human Cells)

Cat. No : CDRP-00399
size:
Target Information
Target Name NGAL/Lipocalin-2
Synonyms Neutrophil gelatinase-associated lipocalin; NGAL; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25; HNL; NGAL
UniProt ID P10148
Accession P80188
Product Details
Expression Host HEK293 Cells
Species Human
Tag C-6His
Molar Mass 21.6 kDa
Sequence Thr 34-Leu 328
Background
LCN2 is iron-trafficking protein involved in multiple processes such as apoptosis; innate immunity and renal development. LCN2 binds iron through association with 2;5-dihydroxybenzoic acid (2;5-DHBA); a siderophore that shares structural similarities with bacterial enterobactin; and delivers or removes iron from the cell; depending on the context. LCN2 is involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis; while iron-free form decreases intracellular iron levels; inducing expression of the proapoptotic protein BCL2L11/BIM; resulting in apoptosis. LCN2 is involved in innate immunity; possibly by sequestrating iron; leading to limit bacterial growth.
Properties
Purity >98% as determined by reducing SDS-PAGE.
Formulation Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.
Storage Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles.

! For research use only. Not intended for any clinical use.