Recombinant Human MVK/Mevalonate Kinase Protein (GST & His Tag)
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Recombinant Human MVK/Mevalonate Kinase Protein (GST & His Tag)

Cat. No : CDRP-00374
size:
Target Information
Target Name MVK/Mevalonate kinase
Synonyms LRBP; MK; MVLK; POROK3
UniProt ID P09237
Accession Q03426
Product Details
Expression Host Baculovirus-Insect Cells
Species Human
Tag N-His & GST
Molar Mass 70.2 kDa
Sequence Tyr 18-Thr 272
Background
Mevalonate kinase belongs to the GHMP kinase family, Mevalonate kinase subfamily. It can be found in a wide variety of organisms from bacteria to mammals. Mevalonate kinase may be a regulatory site in cholesterol biosynthetic pathway. Defects in mevalonate kinase can cause mevalonic aciduria (MEVA). It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia. Defects in mevalonate kinase can also cause hyperimmunoglobulinemia D and periodic fever syndrome (HIDS). HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis.
Properties
Purity >98% as determined by reducing SDS-PAGE.
Formulation Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 2 mM DTT, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.
Storage Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles.

! For research use only. Not intended for any clinical use.