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Recombinant Human LRP10 Protein (His Tag)
Cat. No : CDRP-00312
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| Target Information | |
|---|---|
| Target Name | LRP10 |
| Synonyms | LRP9; MST087; MSTP087 |
| UniProt ID | P07151 |
| Accession | Q7Z4F1-1 |
| Product Details | |
|---|---|
| Expression Host | HEK293 Cells |
| Species | Human |
| Tag | C-His |
| Molar Mass | 47.5 kDa |
| Sequence | Met 1-Thr 287 |
| Background |
|---|
| Various members of the low-density lipoprotein receptor (LDLR) family have been reported to play a role in APP trafficking and processing and are important risk factors in AD. LDLR-related protein 1 (LRP1) shuttles between the trans-Golgi Network (TGN); plasma membrane (PM); and endosomes. LRP1 is a functional APP receptor involved in APP trafficking and processing. LRP1 interacts directly with the ectodomain of APP and colocalizes with APP at the TGN. LRP1 is a novel APP sorting receptor that protects APP from amyloidogenic processing; suggesting that a decrease in LRP1 function may contribute to the pathogenesis of Alzheimer's disease. |
| Properties | |
|---|---|
| Purity | >95% as determined by reducing SDS-PAGE. |
| Formulation | Lyophilized from sterile PBS, pH7.4. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.