Products
Online Inquiry
Recombinant Human LDLR Protein (His Tag/AVI)
Cat. No : CDRP-00295
size:
Target Information | |
---|---|
Target Name | LDLR |
Synonyms | Low-Density Lipoprotein Receptor; LDL Receptor; LDLR; FH; FHC; LDL R; LDL Receptor; LDLCQ2 |
UniProt ID | P06280 |
Accession | P01130 |
Product Details | |
---|---|
Expression Host | HEK293 Cells |
Species | Human |
Tag | C-6His-AVI |
Molar Mass | 90.1 kDa |
Sequence | Gln 30-Ala 247 |
Background |
---|
Low-density lipoprotein receptor 9 (LDL receptor) is a single-pass type I membrane protein which belongs to the LDLR family. It contains 3 EGF-like domains, 7 LDL-receptor class A domains, and 6 LDL-receptor class B repeats. This protein binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, it functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR will result in familial hypercholesterolemia. |
Properties | |
---|---|
Purity | >90% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from a 0.2 μm filtered solution of 50 mM HEPES, 150 mM NaCl, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.