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Recombinant Human LDLR Protein (His Tag)
Cat. No : CDRP-00293
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| Target Information | |
|---|---|
| Target Name | LDLR |
| Synonyms | Low-Density Lipoprotein Receptor; LDL Receptor; LDLR; FH; FHC; LDL R; LDL Receptor; LDLCQ2 |
| UniProt ID | P06132 |
| Accession | NP_000518.1 |
| Product Details | |
|---|---|
| Expression Host | HEK293 Cells |
| Species | Human |
| Tag | C-6His |
| Molar Mass | 84.8 kDa |
| Sequence | Gln 28-Lys 601 |
| Background |
|---|
| Low-Density Lipoprotein Receptor (LDLR) is a transmembrane glycoprotein that plays a critical role in cholesterol homeostasis. LDLR mediates blood cholesterol level by interacting with lipoprotein particles like LDL and VLDL. The extracellular domain of LDLR contains LDL receptor type A (ligand-binding) modules (LA repeats), epidermal growth factor-like modules, and LY repeats containing the YWTD consensus motif that are important in binding and releasing of ApoB-100 and ApoE in lipoprotein particles. The C terminal domain of LDLR inside the cell is required for the receptor internalization. Loss of function mutations in the LDLR gene causes Familial Hypercholesterolemia (FH). |
| Properties | |
|---|---|
| Purity | >90% as determined by reducing SDS-PAGE. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 50 mM HEPES, 150 mM NaCl, pH7.4. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.