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Recombinant Human Insulin Receptor/INSR Protein (GST & His Tag) (Active)
Cat. No : CDRP-00250
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Target Information | |
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Target Name | Insulin Receptor/INSR |
Synonyms | CD220; HHF5; Insulin Receptor |
UniProt ID | P04070 |
Accession | NP_000199.2 |
Product Details | |
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Expression Host | Baculovirus-Insect Cells |
Species | Human |
Tag | N-His & GST |
Molar Mass | 72.3 kDa |
Sequence | Val 23-Gly 258 |
Background |
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INSR (Insulin receptor), also known as CD220, is a transmembrane receptor that is activated by insulin. INSR belongs to theprotein kinase superfamily, and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding to insulin, including IRS1 (insulin receptor substrate 1) and phosphatidylinositol 3'-kinase (PI3K). IRS-1 binding and phosphorylation eventually leads to an increase in the high affinity glucose transporter (Glut4) molecules on the outer membrane of insulin-responsive tissues. INSR isoform long and isoform short are expressed in the peripheral nerve, kidney, liver, striated muscle, fibroblasts and skin, and is found as a hybrid receptor with IGF1R which also binds IGF1 in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibrobasts, spleen and placenta. Defects in Insulin Receptor/INSR are the cause of Rabson-Mendenhall syndrome (Mendenhall syndrome), insulin resistance (Ins resistance), leprechaunism (Donohue syndrome), and familial hyperinsulinemic hypoglycemia 5 (HHF5). It may also be associated with noninsulin-dependent diabetes mellitus (NIDDM). |
Properties | |
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Purity | >98% as determined by reducing SDS-PAGE. |
Formulation | Supplied as sterile solution of 50 mM Tris, 100 mM NaCl, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. |
Storage | Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles. |
! For research use only. Not intended for any clinical use.