Recombinant Human IL-1RAcP/IL1R3 Protein (His Tag)

Cat. No : CDRP-00197

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Target Information
Target Name	IL-1RAcP/IL1R3
Synonyms	Interleukin-1 Receptor Accessory Protein; IL-1 Receptor Accessory Protein; IL-1RAcP; Interleukin-1 Receptor 3; IL-1R-3; IL-1R3; IL1RAP; C3orf13; IL1R3
UniProt ID	P02749
Accession	Q9NPH3

Product Details
Expression Host	HEK293 Cells
Species	Human
Tag	C-His
Molar Mass	39.75 kDa
Sequence	Ala 21-Pro 237

Background
Interleukin-1 Receptor Accessory Protein (IL-1RAcP) is a member of the interleukin-1 receptor family. It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in signal transduction. IL-1RAcP acts as a non-ligand binding accessory component of the receptors for IL1α; IL1βand IL33. IL-1RAcP mediates interleukin-1-dependent activation of NF-kappa-B. It is part of the membrane-bound form of the IL-1 receptor. IL-1 RAcP takes part in the Signaling ways by the formation of a ternary complex containing IL1R1; TOLLIP; MYD88; and IRAK1 or IRAK2. In addition; IL-1RAcP modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.

Background

Interleukin-1 Receptor Accessory Protein (IL-1RAcP) is a member of the interleukin-1 receptor family. It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in signal transduction. IL-1RAcP acts as a non-ligand binding accessory component of the receptors for IL1α; IL1βand IL33. IL-1RAcP mediates interleukin-1-dependent activation of NF-kappa-B. It is part of the membrane-bound form of the IL-1 receptor. IL-1 RAcP takes part in the Signaling ways by the formation of a ternary complex containing IL1R1; TOLLIP; MYD88; and IRAK1 or IRAK2. In addition; IL-1RAcP modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.

Properties
Purity	>85% as determined by reducing SDS-PAGE.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20 mM PBS, 150 mM NaCl, pH7.2.
Reconstitution	Please refer to the printed manual for detailed information.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.