Products
Online Inquiry
Recombinant Human HGFA Protein (His Tag)
Cat. No : CDRP-00127
size:
Target Information | |
---|---|
Target Name | HGFA |
Synonyms | HGFA; MGC138395; MGC138397; RP11-529E10.2 |
UniProt ID | P01019 |
Accession | NP_001519.1 |
Product Details | |
---|---|
Expression Host | HEK293 Cells |
Species | Human |
Tag | C-His |
Molar Mass | 68.2 kDa |
Sequence | Met 1-Pro 250 & Trp 17-Trp 443 |
Background |
---|
HGF activator (HGFA) is a serum-derived serine protease and belongs to the peptidase family S1. HGFA is responsible for the conversion of hepatocyte growth factor (HGF), from the inactive single-chain precursor to the active heterodimeric form, which is a potent mitogen, motogen, and morphogen for liver cells, epithelial cells, and endothelial cells. HGFA is synthesized and secreted by the liver and circulates in the plasma as an inactive single-chain zymogen in normal states. The zymogen is cleaved by thrombin or thermolysin through the endoproteolytic process and forms an active heterodimer linked by a disulfide bond. In turn, the active protease can be inhibited by HGFA inhibitors (HAIs) including HAI-1 and HAI-2. In addition, the HGFA zymogen acquires a strong affinity upon activation and thus may ensure the local action in tissue regeneration in liver, kidney and skin. It has been reported that activation of HGF is a critical limiting step in the HGF/SF-induced signaling pathway mediated by Met, and accordingly, aberrant expression of HGFA is implicated in tumorigenesis and progression. |
Properties | |
---|---|
Purity | >95% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from sterile PBS, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.