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Recombinant Human HBA1 Protein (His Tag)
Cat. No : CDRP-00115
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Target Information | |
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Target Name | HBA1 |
Synonyms | Hemoglobin subunit alpha; Alpha-globin; Hemoglobin alpha chain; HBA1; HBH; HBA-T3 |
UniProt ID | P00797 |
Accession | P69905 |
Product Details | |
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Expression Host | E.coli |
Species | Human |
Tag | N-6His |
Molar Mass | 16.7 kDa |
Sequence | Ala 19-Ser 515 |
Background |
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Hemoglobin subunit alpha 1 (HBA1), also known as α2β2, is a hetero-tetramer consisting of two α and two β subunits held together by non-covalent interactions. Each subunit contains a heme group with an iron atom in the Fe2+ state. Cooperativity of Hemoglobin (Hb) in binding with O2 and allosteric regulatory binding properties with CO2, H+, Cl?, and 2,3-DPG (2,3-bisphosphoglycerate) are based on subunit interactions. HBA1 is the most common type of Hb in adult humans, which mediates the transport of oxygen and carbon dioxide in the blood. In recent years, Hb α and β chains have been found co-expressed in alveolar cells, mesangial cells of the kidney, retinal ganglion cells, hepatocytes and neurons. Endothelial and peripheral catecholaminergic cells express exclusively the α chain, while macrophages present the β chain only. |
Properties | |
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Purity | >83% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from a 0.2 μm filtered solution of 20 mM PBS, 150 mM NaCl, pH7.0. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.